From Bangor via Route 9 (passing lanes):
From Bangor, follow Route 9 North to Calais (approx. 95 miles) to Baring. Turn right onto Route 1 South. Take a right turn at the second red/yellow/green traffic light in Calais to stay on Route 1 South. Continue approx. 25 miles to Perry. Turn left onto Route 190 to Eastport (approx. 7 miles).

From Bangor via Route 1 (scenic route):
From Bangor, follow Route 1 (and 1A)North through Brewer, Ellsworth, Milbridge, Machias, to Perry. (approx. 125 miles). In Perry, take a right onto Route 190 to Eastport (approx. 7 miles).

From St. John, NB Canada:
From St. John, take Route 1 South to the St. Stephen, NB/Calais, Maine border. (approx. 70 miles). Passport Required. Continue on Route 1 South approx. 25 miles to Perry. In Perry, take a left onto Route 190 to Eastport (approx. 7 miles).